PAX-BD : Surrey and Borders Partnership NHS Foundation Trust
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Surrey and Borders Partnership NHS Foundation Trust
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  • About Research

      About Research

      Health and social care research helps us learn about why we become ill and what we can do to stay well. It advances our knowledge so that we can find new treatments, change the way we deliver care, prevent illness and improve the environment, health and wellbeing of local populations.

    • Benefits of Research
    • Frequently Asked Questions
    • Initiating & Delivering Clinical Research
    • Outcome of Research
      • Structured Preparation for Alcohol Detoxification (SPADe)
      • Publications Across the Trust
      • Brief Intervention for Alcohol Misuse in Adults with Mild to Moderate Learning Disabilities (EBI-LD)
  • Current Studies

      Current Studies

      We support research that benefits people who use our services and the communities we serve. We have studies for children and young people, dementia, substance misuse, eating disorders, learning disabilities and mental health.

    • Children and Young People
    • Drug and Alcohol
      • Opiant
    • Eating Disorders
      • EGDI
    • Mental Health
      • Genetic Links to Anxiety And Depression (GLAD study)
      • PAX-BD
      • PPIP2
      • DPIM (Healthy Volunteers)
      • Pharmacogenetics
      • Finger sweat study
      • Urban mind study
      • Cognitive and Neural Networks in Psychiatry
      • MEG
    • Research for Everyone
      • TIHM Survey
    • Memory and Dementia
      • DETERMIND
      • MINDER
      • The causal role of neural activity in neurodegeneration (TIAD)
      • NoDem
    • Learning Disabilities
      • Strata
  • Conducting Research
  • Contact us

Research and Development

PAX-BD

What is the study about?

Those with a diagnosis of bipolar disorder tend to have symptoms around 50% of the time, the most frequent symptom is depression. Most of these individuals would be treated with anti-psychotics and anti-depressants, however, there is limited evidence that this is effective in treating the depressive symptoms.

PAX-BD is trialing whether Pramipexole is an effective medication to treat depressive symptoms in those who have bipolar disorder. Pramipexole is a medication which is used to treat Parkinsons and restless leg syndrome, however, it has been seen to have positive effects on mood as well.

Who can take part?

We are looking for people aged 18+ who are under the care of mental health services and have a diagnosis of bipolar disorder and are currently low in mood. We are looking for people who have tried at least 2 of the following medications: lamotrigine, lurasidone, quetiapine, olanzapine.

What is involved?​​​​​​​

The study lasts for approximately 1 year. This is split into a screening period of 4 weeks, a 52 week treatment phase and a 2 week follow up. 

You will be assigned to either receive Pramipexole or a placebo (you will not know which group you are in). The study drug will be delivered to your home address and you will take this each day and receive regular telephone calls from

Research Assistants who will be checking in on your mood and your symptoms. You will be asked to make occasional visits over the course of the study period to our Abraham Cowley Unit based on the St Peter's Hospital site in Chertsey. We will carry out physical examinations, such as taking your blood pressure and pulse.

How do I get involved?​​​​​​​

We would really like to hear from you if you fit the description above and are interested in taking part to help in the search for effective treatment for depression in those with bipolar disorder. Please email us on research@sabp.nhs.uk or call us on 01372 216584.

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  • Home
  • About Research
    • About Research

    • Benefits of Research
    • Frequently Asked Questions
    • Initiating & Delivering Clinical Research
    • Outcome of Research
      • Outcome of Research

      • Structured Preparation for Alcohol Detoxification (SPADe)
      • Publications Across the Trust
      • Brief Intervention for Alcohol Misuse in Adults with Mild to Moderate Learning Disabilities (EBI-LD)
  • Current Studies
    • Current Studies

    • Children and Young People
    • Drug and Alcohol
      • Drug and Alcohol

      • Opiant
    • Eating Disorders
      • Eating Disorders

      • EGDI
    • Mental Health
      • Mental Health

      • Genetic Links to Anxiety And Depression (GLAD study)
      • PAX-BD
      • PPIP2
      • DPIM (Healthy Volunteers)
      • Pharmacogenetics
      • Finger sweat study
      • Urban mind study
      • Cognitive and Neural Networks in Psychiatry
      • MEG
    • Research for Everyone
      • Research for Everyone

      • TIHM Survey
    • Memory and Dementia
      • Memory and Dementia

      • DETERMIND
      • MINDER
      • The causal role of neural activity in neurodegeneration (TIAD)
      • NoDem
    • Learning Disabilities
      • Learning Disabilities

      • Strata
  • Conducting Research
  • Contact us